细胞自噬与神经退行性疾病机制的研究进展OACSTPCD
Advances in mechanisms of autophagy and neurodegenerative diseases
自噬是真核细胞特有的溶酶体途径降解细胞内代谢物的过程,其变化与阿尔茨海默病(Alzheimer's disease,AD)、帕金森病(Parkinson's disease,PD)等神经退行性疾病的发生发展有密切联系.调节自噬可有效清除神经系统中异常积聚的蛋白质,从细胞水平上缓解疾病进展.由此可见,自噬方向可能是一种治疗神经退行性疾病的有效策略和途径.
Autophagy is a unique process of lysosomal pathway of eukaryotic cells to degrade intracellular metabolites and autophagy dysfunction is closely related to neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's syndrome (PD). Regulating autophagy can effectively remove the protein from abnormal accumulation in the nervous system and alleviate the disease progression from the cellular level. Thus, autophagy may be an effective strategy an…查看全部>>
冯会超
华北理工大学研究生院,河北 唐山 063210
细胞自噬神经退变性疾病α-突触蛋白β-淀粉样蛋白
autophagyneurodegenerativeα-synucleinamyloid β-protein
《临床与病理杂志》 2018 (3)
659-663,5
2014 年河北省政府资助临床医学优秀人才培养项目.This work was supported by the Hebei Provincial Government Foundation of Excellent Talent Training Grogram for Clinical Medicine 2014, China.
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