临床与病理杂志2018，Vol.38Issue(3)：664-669,6.DOI:10.3978/j.issn.2095-6959.2018.03.034
吸入性糖皮质激素对气道高反应性的应用及作用机制
Application of inhaled glucocorticoids to airway hyperresponsiveness and its mechanism
杨柳1
作者信息
- 1. 哈尔滨医科大学附属第二医院麻醉科,哈尔滨 150000
- 折叠
摘要
Abstract
Airway hyperresponsiveness is a strong contraction of the bronchus caused by a variety of physical or chemical stimulation, obvious bronchial spasm constriction is the main pathophysiological characteristics. The most effective clinical anti-inflammatory drugs to treat respiratory diseases are glucocorticoids. Topical application can act on almost all cells in the airways and suppress airway inflammation or prevent inflammatory cells from entering the airways. Inhaled glucocorticoids as a local airway medication can reduce the production of immune inflammatory mediators, inhibit the production of inflammatory factors, and reduce airway hyperresponsiveness. Glucocorticoids regulates gene transcription through certain mechanisms that affect the production and release of most inflammatory mediators. Glucocorticoids by inhalation is very effective for most patients with less systemic side effects.关键词
吸入性糖皮质激素/气道高反应性/作用机制Key words
inhaled glucocorticoid/airway hyperresponsiveness/mechanism引用本文复制引用
杨柳..吸入性糖皮质激素对气道高反应性的应用及作用机制[J].临床与病理杂志,2018,38(3):664-669,6.
