摘要
Abstract
Objective: To investigate the clinical effect of Shudi Pingchan decoction combined with Compound Levodopa in the treatment of paralysis agitans. Methods: 92 patients with paralysis agitans were divided into the control group (n = 46) and the observation group(n = 46). The control group was treated with Compound Levodopa,while the observation group was treated with Shudi Pingchan decoction on the basis of the control group. The composition: Shudihuang(Radix Rehmanniae Preparata) 15 g,Gouqizi(Fructus Lycii) 15 g,Baishao(Radix Paeoniae Alba) 15 g,Sangjisheng(Loranthus Parasiticus) 20 g,Tianma(Gastrodia Elata) 15 g,Ezhu(Curcuma Zedoaria) 15 g, Jiangcan(Stiff Silkworm) 10 g,Tiannanxing(Rhizoma Arisaematis) 15 g,Quanxiefen(Scorpion Powder) 3 g. Observed the clinical efficacy,unified parkinson disease rating scale (UPDRS) score," on" or " off" time,H-Y grading and adverse reactions between the two groups. Results: The effective rate of the observation group 89.13％ was significantly higher than that of the control group 69.57％(P ＜ 0.05). There were statistically significant differences in UPDRS Ⅱ and UPDRS Ⅲ scores at different time points in the observation group before and after treatment (P ＜ 0.05), and the control group was not statistically significant differences before and after treatment (P ＞ 0.05); After 6 months treatment, the total UPDRS score of the observation group was significantly lower than that of the control group (P ＜ 0.05); the scores of UPDRS Ⅲ in the observation group were significantly lower than those in the control group after 2 months',3 months' and 6 months' treatment(P ＜ 0.05); 40 cases in the observation group and 32 patients in control group had obvious " on" and " off" phenomenon,2 months after treatment," on" time in the observation group was significantly prolonged, and the " off" time is shortened. After repeated measures analysis of variance, there was a statistically significant difference in the duration of " on" and " off" time before and after treatment(P ＜ 0.05). The " on" and " off" time in control group had no obvious changes(P ＞ 0.05). There was no significant difference in H-Y grading between groups before treatment (P ＞ 0.05). After statistically analyzed before and after treatment, the H-Y grading of observation group had statistical significant difference(P ＜ 0.01), and the H-Y grading of control group had statistical significant difference(P ＜ 0.01). After treatment, the proportion of the observation group restored to 0 to 2.5 stage was as high as 84.78％, significantly higher than 65.22％ of the control group (P ＜ 0.05). No statistically significant difference was found in the incidence of adverse reactions between groups (P ＞ 0.05). Conclusion: Shudi Pingchan decoction combined with Compound Levodopa in the treatment of paralysis agitans can improve the curative effect and improve the symptoms.关键词
脑梗死/通窍活血汤/药枕/中医药疗法/中西医结合Key words
cerebral infarction/Tongqiao Huoxue decoction/medicine pillow/TCM therapy/combination of traditional Chinese and western medicine分类
医药卫生
