中医药导报2018，Vol.24Issue(9)：31-35,5.
藏药砂生槐子总生物碱生物黏附迷你肠溶片的制备与体内外评价
Preparation and Quality Evaluation of Tibetan Medical Sophora Moorcroftiana Seed Extract Mini Menadhesive Tablets
摘要
Abstract
Objective: To prepare biological adhesive enteric-coated mini tablets for the extraction of sophora moorcroftiana seed in order to increase the retention time and release time of the drug in the intestine. Methods: The dissolution rate of the influence factors was determined through thesingle factor test, then L9(33) used to determine the optimal formulation by orthogonal test. The 3 mm mini core was prepared with the best prescription, and the core was coated with enteric coating. The bioadhesive force of mini core was investigated by self-made adhesion apparatus, and the small animal live imaging technique was used to investigate the retention of the preparations in animals. Results: The best prescription of tablet core is that containing starch and adhesive material ratio was 5∶1, and that the filler is sucrose; The sodium alginate and Carbopol 934 as the proportion of 2∶1, and enteric mini tablet dissolution test showed that the drug release in simulated gastric juice, the cumulative release rate reached above 80％. The core is adhesion in the intestinal tract, showing a small animal in vivo fluorescence imaging technology with the adhesion of enteric mini tablets in vivo. Conclusion: Mini enteric tablets can effectively and the cumulative release rate of good retention in the gastrointestinal tract, to achieve the expected goal of experimental design, as in Tibetan medicine enteric coated tablets and preparation of bioadhesive tablets preparation provides an important reference value.关键词
砂生槐子/总生物碱/生物黏附迷你肠溶片/荧光活体成像Key words
Sophora moorcroftiana seed/Oxymatrine/Mini adhesive tablets/in vivo bioluminescence imaging分类
医药卫生引用本文复制引用
胡春晖,党云洁,孙梦娟,张发斌..藏药砂生槐子总生物碱生物黏附迷你肠溶片的制备与体内外评价[J].中医药导报,2018,24(9):31-35,5.基金项目
青海大学医学院中青年团队项目(2013-KT-1) （2013-KT-1）
青海省科技厅项目(2014-ZJ-716) （2014-ZJ-716）
教育部"春晖计划"(Z2015077) （Z2015077）
