基础医学与临床2018，Vol.38Issue(2)：185-188,4.
姜黄素抑制顺铂诱导人肾小管上皮细胞系HK-2凋亡
Curcumin inhibits apoptosis of HK-2 cell line induced by cisplatin
摘要
Abstract
Objective To investigate whether curcumin could inhibit cisplatin-induced apoptosis of HK-2 cells. Methods Using MTT methods to observe inhibitory effects of curcumin and cisplatin on the proliferation of HK-2 cell. Detecting caspases expression after curcumin and cisplatin treatment by Western blot. Results Cisplatin induced cell apoptosis, and the effect was dose-dependent(P＜0.05).Under the synergistic effect of curcumin and cisplatin on HK-2 cell, the number of apoptosis decreased(P＜0.05). In the same time the expression of Bcl-2 protein increased (P < 0.05) and the expression of Bcl-2 protein decreased (P < 0.05). Conclusions Cisplatin enhances the apoptosis of HK-2 cell in a dose-dependent manner, and is inhibited by curcumin. Curcumin can antagonize cisplatin-induced apoptosis in HK-2 by regulating the expressions of Bax and Bcl-2 protein.关键词
姜黄素/顺铂/HK-2/细胞凋亡Key words
curcumin/cisplatin/HK-2/cell apoptosis分类
医药卫生引用本文复制引用
吕文秀,吴文韬,郑士梅,谢林虎,丁伯平..姜黄素抑制顺铂诱导人肾小管上皮细胞系HK-2凋亡[J].基础医学与临床,2018,38(2):185-188,4.基金项目
国家级大学生创新创业科研项目(20151036800) （20151036800）
