基础医学与临床2018，Vol.38Issue(2)：241-245,5.
噬菌体裂解酶作用机制及用于细菌感染治疗的研究进展
Mechanism and progress of the research on the treatment of bacterial infection with bacteriophage lysin
摘要
Abstract
Bacteriophage lysin is characterized by high stability, wide bactericidal activity and efficacy, and safty. It is able to lyse bacteria specifically and is not susceptible to bacterial resistance. In the presence of phage, phage infecting bacteria and coding for endolysin then it lyse the bacteria, In the absence of the phage, holin assists the endolysin lysis the bacteria from external. In addition, the research progress on the treatment of Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes, and Gram-negative bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, was also discussed in this paper.关键词
噬菌体/裂解酶/治疗/抗菌机制Key words
phage/lysin/therapy/antibacterial mechanism分类
医药卫生引用本文复制引用
朱丹,祝思路,付玉荣,伊正君..噬菌体裂解酶作用机制及用于细菌感染治疗的研究进展[J].基础医学与临床,2018,38(2):241-245,5.基金项目
国家自然科学基金(81100006) （81100006）
山东省自然科学基金(ZR2016HM09) （ZR2016HM09）
