基础医学与临床2018，Vol.38Issue(2)：260-264,5.
内质网应激在肝脏相关疾病中的研究进展
Role of endoplasmic reticulum stress in the pathogenesis of liver diseases
丁文斌 1戴佳敏 1张峰 1王学浩 1饶建华1
作者信息
- 1. 南京医科大学第一附属医院 肝脏外科,江苏 南京 210029
- 折叠
摘要
Abstract
Endoplasmic reticulum stress (ERS) is an important cellular self-protection mechanism. It can activate the unfolded protein response (UPR) that promotes cell survival, but sustained ERS may lead to cell apoptosis. There are a lot of endoplasmic reticulum in the liver cells, and many liver-related diseases are associaled with endoplasmic reticulum stress, such as alcoholic liver disease, non-alcoholic liver disease, toxic liver injury, viral hepatitis, hepatic malignant tumors and hepatic ischemia- perfusion injury. This article will summarize the role of ERS in the pathogenesis of liver-related diseases and the significance of intervention in liver disease.关键词
内质网应激/未折叠蛋白反应/细胞凋亡/肝脏疾病Key words
endoplasmic reticulum stress/unfolded protein response/apoptosis/liver disease分类
医药卫生引用本文复制引用
丁文斌,戴佳敏,张峰,王学浩,饶建华..内质网应激在肝脏相关疾病中的研究进展[J].基础医学与临床,2018,38(2):260-264,5.
