中国当代医药2018，Vol.25Issue(16)：108-110,3.
亚临床甲状腺功能减退症稽留流产患者绒毛蜕膜组织中MMP-9、TSP-1的表达及临床意义分析
Expression and clinical significance of MMP-9 and TSP-1 in chorionic and decidual tissues in missed abortion patients with subclinical hypothyroidism
摘要
Abstract
Objective To investigate the expression and clinical significance of matrix metalloproteinase-9(MMP-9) and thrombospondin-1 (TSP-1) in chorionic and decidual tissues in missed abortion patients with subclinical hypothyroidism. Methods 25 cases of missed abortion patients with subclinical hypothyroidism treated in Department of Obstetrics and Gynecology clinic of our hospital from July 2016 to July 2017 were selected in the study group,and other 25 cases of early pregnant patients for voluntary induced abortion at the same period in our hospital were enrolled in the control group.The clinical data of two groups were retrospectively analyzed,and the MMP-9 positive expression in chorionic and decidual tissues and the integral optical density (IOD) in TSP-1 positive region were compared between the two groups. Results The MMP-9 positive expression rate in the chorionic and decidual tissues in the study group was lower than that in the control group,while the IOD value in TSP-1 positive region was higher than that in the control group,the differences were statistically significant (P＜0.05).Conclusion In missed abortion patients with subclinical hypothyroidism, the expression of MMP -9 in chorionic and decidual tissues decreases significantly while the expression of TSP -1 increases significantly.The above two indexes can inhibit the neovascularization,reduce the invasiveness of trophoblasts and affect the embryo implantation,leading to the occurrence of missed abortion.关键词
亚临床甲状腺功能减退症/稽留流产/绒毛蜕膜/基质金属蛋白酶-9/血小板反应蛋白-1Key words
Subclinical hypothyroidism/Missed abortion/Chorionic and decidual/MMP-9/TSP-1分类
医药卫生引用本文复制引用
文丽,杨小燕,张桂丽,张汉英..亚临床甲状腺功能减退症稽留流产患者绒毛蜕膜组织中MMP-9、TSP-1的表达及临床意义分析[J].中国当代医药,2018,25(16):108-110,3.基金项目
广东省深圳市龙华区科技专项资金项目(20170919A1030240) （20170919A1030240）
