中国当代医药2018，Vol.25Issue(16)：153-156,4.
麝香保心丸联合川芎嗪治疗慢性肺源性心脏病急性加重期的效果观察
Effect observation of Shexiang Baoxin Pills combined with Ligustrazine in the treatment of acute exacerbation of chronic pulmonary heart disease
摘要
Abstract
Objective To explore the effect of Shexiang Baoxin Pills combined with Ligustrazine in the treatment of acute exacerbation of chronic pulmonary heart disease.Methods From June 2016 to May 2017,100 patients with acute exacerbation of chronic pulmonary heart disease were selected as subjects and randomly divided into four groups (A,B, C and D,respectively) according to the random comprehensive sequential method,each group of 25 cases.Group A was given routine western medicine comprehensive treatment.Group B was given Shexiang Baoxin Pills orally on the basis of routine western medicine comprehensive treatment,2 tablets per time,three times per day,used for 10 days.Group C was treated with Ligustrazine 120 mg added into the 250 ml 5％ glucose injection or 0.9％ sodium chloride injection intravenous drip for 10 days.Group D was treated with Shexiang Baoxin Pills orally,2 tablets per time,three times per day, and combination with Ligustrazine 120 mg added into the 250 ml 5％ glucose injection or 0.9％ sodium chloride injection were injected intravenously for 10 days,on the basis of routine Western medicine.The brain natriuretic peptide (BNP),the first second forced expiratory volume ratio (FEV1％),arterial blood oxygen partial pressure (PaO2),arterial blood carbon dioxide partial pressure (PaCO2) and treatment total efficiency before and after treatment were compared with the four groups of patients.Results After treatment,the BNP levels of patients in the A,B,C group were lower than before the treatment,the differences were statistically significant (P＜0.05),while there was no statistically significant difference of patients in group D before and after treatment with BNP levels (P＞0.05).The BNP level of group D was higher than that of group A,B and C,and the differences were statistically significant (P＜0.05).After treatment,the FEV1％ and PaO2 in the four groups were higher than before treatment,and the differences were statistically significant (P＜0.05). After treatment,the FEV1％ and PaO2 in group D were higher than those in the group A,B and C,and PaCO2 was lower than that in the group A, B and C,with statistically significant differences (P＜0.05).The total effective rate of clinical treatment in group D was higher than that in group A,B and C,and the differences were statistically significant (P＜0.05). Conclusion Shexiang Baoxin Pills combined with Ligustrazine in the treatment of acute exacerbation of chronic pulmonary heart disease has a significant effect on improving cardiopulmonary function.关键词
麝香保心丸/川芎嗪/慢性肺源性心脏病急性加重期Key words
Shexiang Baoxin Pills/Ligustrazine/Acute exacerbation of chronic pulmonary heart disease分类
医药卫生引用本文复制引用
万乐乐,易颂刚,敖苏民..麝香保心丸联合川芎嗪治疗慢性肺源性心脏病急性加重期的效果观察[J].中国当代医药,2018,25(16):153-156,4.基金项目
江西省宜春市科技计划项目(JXYC2017KSA026) （JXYC2017KSA026）
