临床输血与检验2018，Vol.20Issue(1)：10-12,3.DOI:10.3969/j.issn.1671-2587.2018.01.004
头孢哌酮钠舒巴坦钠致药物溶血性贫血的分析
A Case Report of Cefoperazone-Sulbactam Sodium-induced Hemolytic Anemia
马春娅 1张晓娟 1罗圆圆 1付丽辉 1何春宇 1于洋 1汪德清1
作者信息
- 1. 100853 北京,中国人民解放军总医院输血科
- 折叠
摘要
Abstract
Objective To report one case of hemolytic anemiainducedby cefoperazone-sulbactam sodium, with theestablishment of diagnostic procedure for the patient. Methods The anti-human globulin test and DAT typing of erythrocytes were performed in the patient. The antibodies against the drugs weredetected by drug-sensitized erythrocytes and the hemolytic and coagulation index were analyzed. Results DAT was positive and DAT typingshowed IgG+C3, and antibodies against cephalosporins was present in theserumof the patient, the Hb decreased from 122g / L to 80g / L after treatment and the PLT from 90X 109/ L to 17×109/L. Inversely, LDH increased from 189.5 u mol / L to 347.2 μ mol / L and AST increased from 25.7 U / L to 63.5 U / L. PT prolonged from 13.4 s to 20.9 s and APTT from 35.8 s to 56.6 s, with the INR extending from 1.19 to 1.8. Conclusion Hemolytic anemiamay occurin the patient following cefoperazone-sulbactam sodium administration.关键词
头孢哌酮钠舒巴坦钠/溶血性贫血/抗人球蛋白试验/药物抗体Key words
Cefoperazone-sulbactam sodium/Hemolytic anemia/Anti-human globulin test/Antibodies against drug分类
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马春娅,张晓娟,罗圆圆,付丽辉,何春宇,于洋,汪德清..头孢哌酮钠舒巴坦钠致药物溶血性贫血的分析[J].临床输血与检验,2018,20(1):10-12,3.
