临床输血与检验2018，Vol.20Issue(1)：23-28,6.DOI:10.3969/j.issn.1671-2587.2018.01.009
抗-HCV反应性献血者淘汰与归队模式的探讨
A Detection Strategy for Rejection and Rejoin of Blood Donors with Anti-HCV PositiveReactivity
摘要
Abstract
Objective This study aimed at investigating the recalling of blood donors in Dalian who had been identified aspositiveanti-HCVcarriers by routine screening methods.Methods Anti-HCV positive samples that had been preliminarily screened by routine screening were re-examined with ELISA, NAT and electro-chemiluminescence assay in Dalian Blood Center from January 2013 to July 2015. The time and intervalof recalling was evaluated. Results A total of 192065 blood donorswere screened and 679 (0.35％) cases wereprimarily identified to beanti-HCV positive. Among them77 cases were followed upby repeated combinative detections stated above. No significant difference of ELISA positive rate between various recalling times and intervals (P=0.106, P=0.353, respectively) was seen in the blood donors whoshowed both negative electro-chemi luminescence assay and NAT.Thus twotimes of recalling and longer than 3 monthsof interval weredeterminedas the appropriate recalling strategy. Conclusion The screen methods routinely usedis insufficient to avoid the occurrence of false positivitiesthat might be related tounqualified regents and/or uncaliberated instruments. A deep approach is needed to optimize thestrategy of laboratory examinations for rejectionof the anti-HCV positive cases or rejoin of qualified blood donors in order toensure the safety of resource.关键词
献血者归队/核酸检测/抗-HCVKey words
Rejoin of blood donors/Nucleic acid test/Anti-HCV分类
医药卫生引用本文复制引用
刘颖,邓雪莲,周磊,梁晓华..抗-HCV反应性献血者淘汰与归队模式的探讨[J].临床输血与检验,2018,20(1):23-28,6.基金项目
本课题受卫生部医药卫生科技发展研究中心专项课题(No.28-8-3)资助 （No.28-8-3）
