临床与实验病理学杂志2018，Vol.34Issue(3)：284-288,5.DOI:10.13315/j.cnki.cjcep.2018.03.010
垂体细胞瘤及其罕见室管膜样亚型的临床病理分析
Clinicopathological study of pituicytoma and its rare ependymal variant
司海鹏 1王剑蓉 1章宜芬 1王震 2张智弘2
作者信息
- 1. 南京中医药大学附属医院病理科,南京 210029
- 2. 南京医科大学第一附属医院病理科,南京 210029
- 折叠
摘要
Abstract
Purpose To study the clinicopathological, immunophynotypic features of pituicytoma and its rare ependymal variant with discussion of its diagnosis and differential diagnosis. Methods 7 cases of pituicytoma, including 6 conventional pituicytomas and 1 ependymal variant tumor, were evaluated by HE staining and immunohistochemistry, and the relevant literatures were reviewed. Results Microscopically, the tumors were composed of closely packed plump spindle cells arranged in short fascicle and storiform pattern in 6 conventional pituicytomas, and whorl and papillary architecture with obvious perivascular rosette formation in the ependymal variant tumor. Immunohistochemically, all tumor cells were diffuse positive for S-100 and TTF-1, but negative for IDH1 R132H, Olig-2, CD34, NF, Syn, CgA, and pituitary hormones. Ki-67 proliferation index was less than 2％ in all cases. GFAP and EMA were only focally positive in conventional pituicytomas, whereas GFAP was diffuse positive in ependymal variant tumor with EMA dot-like staining in more than half of tumor cells. Conclusion Pituicytoma is a rare low grade glioma derived from neurohypophysis. To study helps recognition of extending morphological spectrum of pituicytoma and its new variant, which is important for its differential diagnosis consideration and clinical therapy.关键词
垂体细胞瘤/室管膜样/免疫表型/诊断/鉴别Key words
pituicytoma/ependymal/immunophenotype/diagnosis/differential分类
医药卫生引用本文复制引用
司海鹏,王剑蓉,章宜芬,王震,张智弘..垂体细胞瘤及其罕见室管膜样亚型的临床病理分析[J].临床与实验病理学杂志,2018,34(3):284-288,5.
