南京医科大学学报（自然科学版）2018，Vol.38Issue(4)：556-561,6.DOI:10.7655/NYDXBNS20180430
长链非编码RNA遗传多态性作为肿瘤标志物的研究进展
Research progress of genetic polymorphisms in long non-coding RNAs as tumor biomarkers
摘要
Abstract
Long non-coding RNAs(lncRNAs)are a class of RNA molecules with length longer than 200 nucleotides regulating gene expression and playing an important role in the physiological and pathological process, differential expression of lncRNA is significantly associated with tumorigenesis and tumor progression. LncRNA gene variants can alter the genetic structure, led to wide polymorphisms of lncRNA genes which involved in carcinogenesis, metastasis and prognosis. They are expected to become novel tumor biomarkers and therapeutic targets. This review summarized the recent progresses worldwidely to explore the importance of lncRNA gene polymorphisms as potential clinical tumor markers in the risk assessment, curative effect prediction and prognostic judgment.关键词
长链非编码RNA/多态性/肿瘤/标志物Key words
long non-coding RNA/polymorphism/neoplasm/biomarker分类
医药卫生引用本文复制引用
许桃,何帮顺,林康,潘玉琴,孙慧玲,王书奎..长链非编码RNA遗传多态性作为肿瘤标志物的研究进展[J].南京医科大学学报（自然科学版）,2018,38(4):556-561,6.基金项目
国家自然科学基金(81472027) （81472027）
