山东中医杂志2018，Vol.37Issue(6)：452-455,4.DOI:10.16295/j.cnki.0257-358x.2018.06.004
从改善肠黏膜屏障论大黄煎保留灌肠治疗肝硬化自发性细菌性腹膜炎
Exploration of Dahuang Decoction Retention Enema for Spontaneous Bacterial Peritonitis in Liver Cirrhosis From Improving Intestinal Mucosa Barrier
摘要
Abstract
Spontaneous bacterial peritonitis (SBP) is one of the common and serious complications in patients with liver cirrhosis ascites. When there is liver cirrhosis ascites, liver function become deteriorated and portal hypertension will appear, both leading to retarded blood circulation in the intestinal wall and damaged intestinal mucosal barrier, and finally resulting into improved intestinal permeability. Besides, transportation in the intestines tends to cost more time, and there will be excessive multiplication of bacteria and over-secretion of endotoxin, and the intestinal environment will be destroyed. Also there is the decline of immune function in the host, and bacterial translocation is likely to occur, eventually leading to spontaneous bacterial peritonitis. Dahung Decoction could improve the function of intestinal mucosa, reduce intestinal permeability, accelerate the intestinal transport function, and reduce the multiplication of bacteria and secretion of endotoxin. The effect of Dahuang Decoction retention enema for SBP in liver cirrhosis was discussed from improving intestinal mucosa barrier.关键词
肝硬化/自发性细菌性腹膜炎/肠黏膜屏障/大黄煎/保留灌肠Key words
liver cirrhosis/spontaneous bacterial peritonitis/intestinal mucosal barrier/Dahuang Decoction/retention enema分类
医药卫生引用本文复制引用
周莹,王振常..从改善肠黏膜屏障论大黄煎保留灌肠治疗肝硬化自发性细菌性腹膜炎[J].山东中医杂志,2018,37(6):452-455,4.基金项目
国家自然科学基金项目(编号:GJJ16018) （编号:GJJ16018）
广西医疗卫生适宜技术项目(编号:S201676) （编号:S201676）
