外科理论与实践2018，Vol.23Issue(2)：158-165,8.DOI:10.16139/j.1007-9610.2018.02.016
乳腺癌骨转移骨相关事件危险因素分析:系统复习及104例病人回顾分析
Risk factors analysis of skeletal-related events in breast cancer patients with bone metastases: a systematic review and retrospective analysis of 104 cases
摘要
Abstract
Objective To explore the risk factors of skeletal-related event (SRE) in breast cancer patients with bone metastases in order to provide clinical base for early prevention of SRE. Methods A systematic literature search from PubMed, Web of Science, CNKI, VIP and Wanfang Data was conducted for the study on risk factors of SRE in breast cancer patients with bone metastases published in Chinese or English between January 1 2000 and October 31 2017. Then relevant information and conclusion were extracted. A total of 104 breast cancer patients with bone metastases from April 2004 to December 2016 in Zhongshan Hospital Fudan University and Shanghai Huangpu District Central Hospital were followed up for SRE. The risk factors of SRE were analyzed. Results Six literatures met the inclusion criteria and were included, which provided univariable and/or multivariable analysis of the risk factors of SRE including patient age, ER/PR/HER2, histological/nuclear grade, clinical stage of disease, duration of bone metastases, number of bone metastases sites and type of surgery. Most studies supported later clinical stage, longer duration of bone metastases and more sites of bone metastases were risk factors of SRE although the conclusions of 6 literatures were different slightly. During median followup of 60 months, 58 of 104 cases occurred SRE. Both primary distant metastasis (P=0. 017) and multiple bone metastases sites (P=0. 008) were independent risk factors of SRE by univariable and multivariable analysis. Similar results were gotten in retrospective study and systematic review. Conclusions It was shown by systematic review and retrospective analysis with 104 cases that later clinical stages, longer duration of bone metastases and more bone metastases sites were probably the risk factors of SRE. Nevertheless, age, molecular classification of breast cancer, histological/nuclear grade or surgery type etc. were not necessarily related to SRE.关键词
乳腺癌/骨转移/骨相关事件/危险因素Key words
Breast cancer/Bone metastases/Skeletal-related event/Risk factors分类
医药卫生引用本文复制引用
胡光富,杨为戈,杨子昂,王红,朱玮,仇晓春,张宏伟,裔海鹰..乳腺癌骨转移骨相关事件危险因素分析:系统复习及104例病人回顾分析[J].外科理论与实践,2018,23(2):158-165,8.基金项目
复旦大学附属中山医院青年基金(2016 ZSQZ54) （2016 ZSQZ54）
上海市科委2014年度科技创新行动计划(14411950302) （14411950302）
