现代医院2018，Vol.18Issue(5)：701-703,3.DOI:10.3969/j.issn.1671-332X.2018.05.023
阳江地区地中海贫血常见基因类型的调查分析
Investigation and Study of Common Gene Types of Thalassemia in Yangjiang
摘要
Abstract
Objective To explore the distribution of common gene types of thalassemia in Yangjiang, Guangdong, so as to provide a theoretical basis for clinical diagnosis, prevention and treatment. Methods A total of 9, 277 cases were collected from the Department of gynaecologic outpatient, antenatal clinic, outpatient department of Pediatrics and children's health care department from April 2015 to April 2017. PCR + conduction hybridization was used to detect alpha thalassemia and beta thalassemia. Results In 9 277 cases, the detection of α thalassemia in 1 711 cases, accounting for 18. 44％(1 711/9 277); detection of thalassemia in 671 cases, accounting for 7. 24％ (671/9 277), there are 3 kinds of β thalassemia homozygote, α thalassemia and β thalassemia with 100 cases, accounting for 1. 08％ (100/9 277), which detected 16 α thalassemia gene type 14 β thalassemia gene type. Conclusion Guangdong Yangjiang area of αthalassemia by ～(--SEA)/αα and β thalassemia major in β～(CD41-42)/βN and β～(654)/β～N, β～(-28)/β～N, α and β thalassemia gene type compound less investigation for diagnosis, treatment and prevention of thalassemia has important significance, is worth promoting in clinical.关键词
α地中海贫血/β地中海贫血/基因类型/阳江地区Key words
Alpha Thalassemia/Beta Thalassemia/Geno Type/Yangjiang Area分类
医药卫生引用本文复制引用
陈文锋,刘恩赐,李桦..阳江地区地中海贫血常见基因类型的调查分析[J].现代医院,2018,18(5):701-703,3.基金项目
阳江市医疗卫生科技计划项目(社发〔2015〕14) （社发〔2015〕14）
