现代医院2018，Vol.18Issue(5)：731-733,3.DOI:10.3969/j.issn.1671-332X.2018.05.033
小檗碱片联合二甲双胍治疗2型糖尿病效果评价
Effectiveness Evaluation Analysis on Berberine Tablets Combination with Metformin Treating Type 2 Diabetes
摘要
Abstract
Objective To explore the clinical effect of Berberine tablets combination with Metformin treating type 2 diabetes (T2DM). Methods Of 80 cases of T2DM were randomly divided into control group and treatment group, 40 cases each group. The control group was given the treatment of Metformin, and the treatment group was given an additional treatment of Berberine tablets. After 3 months treatment, the indexes of blood sugar levels, HOMA-β, HOMA-IR and inflammatory factor were compared between the two groups. Results After treatment, the levels of FPG, 2hPG and HbA1c in the treatment group were all obviously lower than the control group (P＜0. 05). The indexes of HOMA-β and HOMA-IR in the treatment group were lower than the control group (P＜0. 05). And the levels of CRP, IL-6 and TNF-α in the treatment group were all lower than the control group (P＜0. 05). Conclusion The treatment of Berberine tablets combination with Metformin could alleviate inflammatory response, promote secretion of insulin βcell, increase cell insulin sensitivity and achieve a variety of hypoglycemic effect.关键词
2 型糖尿病/小檗碱片/二甲双胍/效果评价Key words
Type 2 Diabetes/Berberine Tablets/Metformin/Effectiveness Evaluation分类
医药卫生引用本文复制引用
范晨,李颖,宋含平,王琦..小檗碱片联合二甲双胍治疗2型糖尿病效果评价[J].现代医院,2018,18(5):731-733,3.基金项目
珠海市科技计划项目(2015A1026) （2015A1026）
