中国肺癌杂志2018，Vol.21Issue(4)：303-309,7.DOI:10.3779/j.issn.1009-3419.2018.04.14
随访观察——主病灶切除的胸腔内播散腺癌或鳞癌患者的可选治疗策略
Observation-An Favorable Option Forthoracic Dissemination Patients with Lung Adenocarcinoma or Squamous Carcinoma
陈英 1李巍 2唐文芳 3杨学宁 2钟文昭2
作者信息
- 1. 510515 广州,南方医科大学第二临床医学院
- 2. 510080 广州,广东省肺癌研究所,广东省人民医院&广东省医学科学院
- 3. 518000 佛山,佛山市第一人民医院
- 折叠
摘要
Abstract
Background and objective Surgery was not standard-of-care of patients with advanced lung cancer. However, a serial of retrospective studies demonstrated that thoracic dissemination (M1a) patients could benefit from contraindicated surgery. After non-standard treatment, how should these patients choose following treatment approaches? Herein, we conducted this retrospective study to explore subsequent optimal treatment approaches. Methods Different therapeutic approaches were evaluated by comparing progression-free survival (PFS), overall survival (OS), time to treatment interval (TTI) using the Kaplan-Meier method and Log-rank test. A Cox proportional hazards regression model was used for multivariate analysis. Results 141 eligible were enrolled. The median PFS of chemotherapy group, targeted therapy group and observation group were 14.7, 41.0 and 31.0 months, respectively (95％CI: 19.01-26.01; P＜0.001). There was no significantly statistically difference between median PFS of targeted group and observation group (P=0.006). The median OS were 39.0, 42.6 and 38.1 months (95％CI: 32.47-45.33; P=0.478). The median PFS and OS of TTI<3 months and TTI ≥3 months were 15.2 months versus 31.0 months (95％CI: 19.01-26.06; P＜0.001) and 41.7 months versus 38.7 months (95％CI: 32.47-45.33; P=0.714). Multivariate analyses revealed gender (P=0.027), lymph node status (P=0.036) and initial therapy (P＜0.001) were independent prognostic factors for PFS. Conclusion Observation did not shorten survival of thoracic dissemination patients with lung adenocarcinoma or squamous carcinoma, therefore, it could be an favorable option. But prospective randomized controlled study was needed to confirm its validity.关键词
腺癌/鳞癌/胸腔内播散/随访观察Key words
Adenocarcinoma/Squamous carcinoma/Thoracic dissemination/Observation引用本文复制引用
陈英,李巍,唐文芳,杨学宁,钟文昭..随访观察——主病灶切除的胸腔内播散腺癌或鳞癌患者的可选治疗策略[J].中国肺癌杂志,2018,21(4):303-309,7.
