中国实用妇科与产科杂志2018，Vol.34Issue(5)：559-562,4.DOI:10.19538/j.fk2018050120
减量降调长方案与拮抗剂方案在卵巢储备功能低下患者中的临床疗效观察
Clinical effect of reduced dose gonadotropin releasing hormone agonist long protocol and gonadotropin releasing hormone antagonist protocol in patients with decreased ovarian reserve
席思思 1杨慕坤 1曾诚 1徐阳 1尚鶄 1薛晴1
作者信息
- 1. 北京大学第一医院妇产科,北京 100034
- 折叠
摘要
Abstract
Objective To compare the clinical effect of reduced dose gonadotropin releasing hormone(GnRH)agonist long protocol with that of GnRH antagonist protocol in patients with decreased ovarian reserve in IVF / ICSI cycles. Methods From January 2012 to April 2016,women with decreased ovarian reserve receiving IVF-ET and ICSI in Peking University First Hospital Reproductive Center clinic were included in this study. A total of 84 cycles received controlled ovarian stimulation by using reduced dose GnRH agonist long protocol and another 84 cycles by GnRH antagonist protocol.The pregnant outcomes between the two groups were compared.Results The numbers of oocytes,fertilization embryo,embryo and transferable embryo were significantly higher in reduced dose GnRH agonist long protocol group (5.6 vs. 3.3,3.7 vs. 2.4,3.8 vs. 2.4,3.3 vs. 2.1,P＜0.01). The usage of gonadotropins and duration of controlled ovarian stimulation in GnRH antagonist protocol group were significantly less than that in reduced dose GnRH agonist long protocol group(2591.1U vs. 3402.7U,8.3d vs. 11.3d,P＜0.01). No significant difference was found in implantation rate,clinical pregnancy rate,abortion rate or ectopic pregnancy rate of each fresh embryo transfer cycle between the 2 groups. No significant difference was found in cumulative clinical pregnancy rate of each oocyte retrieval cycle between the 2 groups. Conclusion The advantage of GnRH antagonist protocol is less dosage of gonadotropin. The number of oocyte retrieved and transferable embryo number in reduced dose long protocol are more.关键词
卵巢储备功能低下/减量降调长方案/拮抗剂方案Key words
decreased ovarian reserve/reduced dose GnRH agonist long protocol/gonadotropin releasing hormone antagonist protocol分类
医药卫生引用本文复制引用
席思思,杨慕坤,曾诚,徐阳,尚鶄,薛晴..减量降调长方案与拮抗剂方案在卵巢储备功能低下患者中的临床疗效观察[J].中国实用妇科与产科杂志,2018,34(5):559-562,4.
