中国兽医科学2018，Vol.48Issue(5)：641-648,8.DOI:10.16656/j.issn.1673-4696.2018.0102
雏鸭感染H5N1亚型禽流感病毒后主要组织器官超微病理变化及病毒抗原分布的动态变化研究
Ultrastructural pathologic changes and detection of viral antigen distribution in major tissues and organs of ducks infected with H5N1 avian influenza virus
摘要
Abstract
The ultrastructural pathologic changes and detection of viral antigen distribution in major organs and tissues of ducks infected with H5N1 avian influenza virus were studied by electron microscope and RT-PCR. It is helpful for the pathogenic mechanism of H5N1 avian influenza virus. The results showed that the detection of antigen was in all the parenchymal organs of ducks infected with AIV on day 3-7 post-infection,but there was a significant difference between the time of virus emergence and the duration. In liver and pancreas the detection of virus appeared the shortest,the duration is the longest; The ultrastructural pathologic changes were mainly the number of lymphocytes in the immune organs of ducks infected with AIV,such as the bursa,spleen and thymus was decreased,and the nucleus pycnosis, chromatin edge set or dissolved; The nucleus of alveolar epithelial cell is pycnosised and deformed. The H5N1 avian influenza virus had tissue tropism extensively and appeared obvious cell degeneration and necrosis. It may be an important reason for the pathogenicity of the H5N1 avian influenza virus.关键词
H5N1亚型禽流感病毒/雏鸭/组织器官/超微病理变化/病毒抗原分布Key words
H5N1 avian influenza virus/ducks/tissue and organ/ultrastructural pathologic changes/viral antigen distribution分类
农业科技引用本文复制引用
田伟,仇铮,刘明,郑世民..雏鸭感染H5N1亚型禽流感病毒后主要组织器官超微病理变化及病毒抗原分布的动态变化研究[J].中国兽医科学,2018,48(5):641-648,8.基金项目
国家自然科学基金项目(30371066) （30371066）
