中国兽医科学2018，Vol.48Issue(6)：743-749,7.DOI:10.16656/j.issn.1673-4696.2018.0125
B细胞永生化方法的研究进展
Progress in Bcell immortalization methods
摘要
Abstract
Methods on immortalization of Bcell are always a research focus. How to keep the Bcell continuous propagation and expression of antibodies plays a vital role in the development of therapeutic and diagnostic antibody drugs and products. Methods for immortalizing Bcells include hybridoma technology, infection with Epstein-Barr virus or SV40 virus, and genetic modification of Bcell. The immortalized Bcells which can rapidly and efficiently produce monoclonal antibodies and overcome immune rejection among different species, are therefore an ideal source of monoclonal antibodies. This article mainly summarizes the recent research progresses and future direction in Bcell immortalization, which could provide some references for people in this research area.关键词
B细胞/单克隆抗体/永生化Key words
Bcell/monoclonal antibody/immortalization分类
农业科技引用本文复制引用
王省,李坤,卢曾军,汪肖肖,谯雨,刘在新,曹轶梅..B细胞永生化方法的研究进展[J].中国兽医科学,2018,48(6):743-749,7.基金项目
国家自然科学基金项目(31372422) （31372422）
