中国实用内科杂志2018，Vol.38Issue(3)：236-241,6.DOI:10.19538/j.nk2018030115
来氟米特治疗成人激素依赖肾病综合征71例疗效分析
Efficacy of leflunomide in the treatment of adults with steroid-dependent nephrotic syndrome.
摘要
Abstract
Objective To observe the efficacy and safety of leflunomide (LEF) in the treatment of adults with steroid-dependent nephrotic syndrome (SDNS). Methods Analyze the prednisone use and relapse of nephrotic syndrome of adult patients with SDNS retrospectively. Compare the frequency of relapse and the minimum maintenance dose of prednisone in the mono-prednisone period(mPred)with the combined LEF period(Pred+LEF). Results Totally 71 patients were analyzed. Compared with mPred period, the frequency of recurrence reduced from 1. 7 (1. 2～2. 6)times·patient-1·year-1to 0 (0～0. 3)times·patient-1·year-1in Pred+LEF period (P<0. 01), and the risk of relapse decreased from 90. 1％ to 9. 9％ at 1 year. The minimum maintenance dose of prednisone was reduced from 20. 0 15. 0～30. 0) mg /d to (1. 3～2. 5) mg /d (P<0. 01), and the average daily dosage of prednison decreased from 32. 9(24. 8～38. 0) mg to 12. 4 (10. 2～15. 1)mg (P<0. 01). Severe adverse events were not reported during follow-up. Conclution LEF can significantly decrease the relapse of SDNS and the use of steroid.关键词
来氟米特/激素依赖/肾病综合征Key words
leflunomide/steroid-dependent/nephrotic syndrome分类
医药卫生引用本文复制引用
涂远茂,张丽华,王霞,曾彩虹,章海涛,李世军..来氟米特治疗成人激素依赖肾病综合征71例疗效分析[J].中国实用内科杂志,2018,38(3):236-241,6.基金项目
国家自然科学基金(81270799) （81270799）
