中国实用内科杂志2018，Vol.38Issue(5)：455-458,4.DOI:10.19538/j.nk2018050111
环孢素A糖皮质激素治疗成人获得性纯红细胞再生障碍疗效对照研究
Comparison of cyclosporine A with corticosteroids in the treatment of adult patients with acquired pure red cell aplasia
摘要
Abstract
Objective To assess the effect of cyclosporine A (CsA) and corticosteroids (CS) in the treatment of adult patients with acquired pure red cell aplasia (PRCA). Methods Clinical data of 42 cases receiving cyclosporine A (CsA), and/or corticosteroids (CS), or other immunosuppressive agents were retrospectively analyzed, including CsA (n=16), CS (n=13), CsA in combination with CS (n=6), or other immunosuppressive agents (n=4). Results The initial response rates were similar among these patients (75.0％, 46.2％, 66.7％, 75.0％, P=0.456). The cumulative response rates in patients receiving CsA, CS, CsA in combination with CS, or other immunosuppressive agents were 69.6％ (16/23), 50.0％ (7/14), 71.4％ (5/7), 42.9％ (6/14), respectively (P=0.376); the cumulative rates of CR were 26.1％ (6/23), 28.6％ (4/14), 57.1％ (4/7), 14.3％ (2/14), respectively (P=0.284). In 27 refractory and relapsed PRCA patients, 11 out of 17 patients (64.7％) achieved remission by CsA and/or CS regimen, while 3 of 10 patients (30.0％) responded to other immunosuppressive agents (P=0.120). Conclusion CsA and/or CS are similarly effective in treating PRCA. For patients with relapse or refractory PRCA, there are no satisfactory treatments if CsA and/or CS fail.关键词
贫血/再生障碍/红细胞/环孢素A/糖皮质激素Key words
anemia/aplasia/red cell/cyclosporine A/corticosteroids分类
医药卫生引用本文复制引用
吴雪梅,张建富,洪鸣,朱雨,李建勇,何广胜,陆星羽,何耀,王素丽,沈文怡,乔纯,吴雨洁,卢瑞南,王帅..环孢素A糖皮质激素治疗成人获得性纯红细胞再生障碍疗效对照研究[J].中国实用内科杂志,2018,38(5):455-458,4.基金项目
国家科技攻关项目(2014BAI09B12) （2014BAI09B12）
卫生部科研基金(201202017) （201202017）
江苏省医学重点项目(BL2014086) （BL2014086）
江苏省普通高校优势学科(JX10231801) （JX10231801）
