中国实用内科杂志2018，Vol.38Issue(5)：459-462,4.DOI:10.19538/j.nk2018050112
基于体积测量的18F-FDG PET-CT代谢参数与非小细胞肺癌分期的相关性研究
Correlation between volume-based 18F-FDG PET-CT metabolic parameters and staging in patients with non-small cell lung cancer
摘要
Abstract
Objective To evaluate the correlation between metabolic tumor burden and initial staging in patients with non-small cell lung cancer (NSCLC). Methods Clinical data of 86 NSCLC patients with TNM stage IA-IV who underwent 18F-FDG PET-CT from December 2012 to December 2015 were retrospectively analyzed. SUVpeak, MTV and TLG of primary cancer on PET-CT images were measured and their association with TNM stage was analyzed by One-way ANOVA and Spearman correlation. Results The MTV, TLG and SUVpeakof primary cancer were significantly different among clinical TNM stage groups (all P<0.05). Both MTV and TLG were significantly positively correlated with tumor stage, and correlation coefficients were 0.72 and 0.69, respectively (all P<0.05). Also positively correlated with metastatic stage on a certain degree, and correlation coefficients were 0.26 and 0.29 (all P<0.05), respectively. While SUVpeak was positive correlated with tumor, node and metastatic stages, and correlation coefficients were 0.38, 0.24, 0.26 (all P<0.05), respectively. Conclusion Volume-based 18F-FDG PET-CT parameters of primary NSCLC lesions on PET-CT are closely related to clinical TNM stage. The higher the value of MTV and TLG, the higher the T staging of NSCLC patients. In addition, SUVpeak is positively correlated to T, N and M stages on a certain extent.关键词
非小细胞肺癌/18F-FDG PET-CT/分期/肿瘤代谢负荷Key words
non-small cell lung cancer/18F-FDG PET-CT/staging/metabolic tumor burden分类
医药卫生引用本文复制引用
杨之光,孙洪赞,黄仁艳..基于体积测量的18F-FDG PET-CT代谢参数与非小细胞肺癌分期的相关性研究[J].中国实用内科杂志,2018,38(5):459-462,4.基金项目
辽宁省重点研发计划指导计划项目(2017225012) （2017225012）
