中国现代医学杂志2018，Vol.28Issue(9)：65-69,5.DOI:10.3969/j.issn.1005-8982.2018.09.012
开角型青光眼患者结膜微血管结构的临床研究
Experimental study of conjunctival microvascular system in open-angle glaucoma patients
摘要
Abstract
Objective To investigate the application of functional slit lamp biomicroscopy (FSLB) in mapping hemodynamics conjunctiva microcirculation of open-angle glaucoma. Methods The hemodynamics of conjunctival micro-vessels in 18 patients with open angle glaucoma were recorded by FSLB and were divided into 2 groups: right eye group (group A) and left eye group (group B). The spherical conjunctiva was imaged by a high-resolution digital camera. The nMPMs were recorded at a high imaging rate of 60 frames per second and a high magnification of × 210 with images obtained. Vascular density and hemodynamics of conjunctival nMPMs were identified using customized software. Results No significant differences in the density, length, diameter, fretting and venous flow velocity of conjunctival micro-vessels were observed between group A and group B (P ＞ 0.05). The velocity of micro-artery and veinsin the upper and lower sides of 2 groups were significantly higher than those in nasal and temporal side (P ＜ 0.05). Statistically significant differences in microvascular density, length and diameter were observed in both groups (P ＜ 0.05). The rank of micro-vessel density is as listed from highest to lowest: temporal / nasal, lower, above. Conclusions FSLB can effectively detect hemodynamics changes in conjunctival microcirculation in open angle glaucoma patients.关键词
开角型青光眼/结膜/血流动力学/功能裂隙灯活体显微镜Key words
open-angle glaucoma/conjunctiva/microvascular/functional slit lamp biomicroscopy分类
医药卫生引用本文复制引用
刘康成,邵毅,叶蕾,骆仲舟,钟菁,容蓉,刘荣强,朱佩文,姜楠,袁进..开角型青光眼患者结膜微血管结构的临床研究[J].中国现代医学杂志,2018,28(9):65-69,5.基金项目
国家自然科学基金(No: 81400372, 81400424, 81660158) （No: 81400372, 81400424, 81660158）
江西省远航工程(No: 2014022 ) （No: 2014022 ）
江西省自然科学基金重大项目(No: 2016ACB21017 ) （No: 2016ACB21017 ）
江西省青年科学基金(No: 20151BAB215016 ) （No: 20151BAB215016 ）
江西省科技支撑计划项目(No: 20151BBG70223 ) （No: 20151BBG70223 ）
