转化医学杂志2018，Vol.7Issue(1)：35-38,4.DOI:10.3969/j.issn.2095-3097.2018.01.009
替普瑞酮联合贝前列素钠治疗幽门螺杆菌阴性慢性萎缩性胃炎疗效观察
Therapeutic effect of teprenone combined with beraprost sodium in chronic atrophic gastritis without Helicobacter pylori infection
盛晓燕 1彭朝胜 2田力 2王宇 2杨璐 2夏菁2
作者信息
- 1. 330024 江西 南昌, 南昌大学附属三三四医院内科
- 2. 100048 北京, 海军总医院特需医疗部
- 折叠
摘要
Abstract
Objective To investigate the therapeutic effect of teprenone combined with beraprost sodium in chronic atrophic gastritis (CAG) without Helicobacter pylori infection. Methods The survey was conducted in 120 subjects selected from our hospital between February 2012 and May 2016. Based on the diagnostic criteria of CAG, the subjects were divided into two groups: observation group (n = 60) and control group (n = 60). The control group was treated with teprenone, while the observation group was treated with compound beraprost sodium and teprenone. The curative efficacy, improvement of clinical symptoms, pathological changes of the gastric mucosa and adverse drug reaction were observed and compared. Results After treatment, the observation group had a total semiotic effective rate of 91.7％, which was significantly higher than that in the control group(75.0％) (P＜0.05). The pathological improvement rate in observation group (81.7％) was significantly higher than that in contral group (65.0％) (P ＜ 0.05). The adverse drug reaction of two groups had no statistically significant difference. Conclusion Combined teprenone with beraprost sodium in treating CAG without Helicobacter pylori infection is effective, and can significantly improve clinical symptoms and gastric mucosal lesions.关键词
替普瑞酮/贝前列素钠/慢性萎缩性胃炎Key words
Teprenone/Beraprost sodium/Chronic atrophic gastritis (CAG)分类
医药卫生引用本文复制引用
盛晓燕,彭朝胜,田力,王宇,杨璐,夏菁..替普瑞酮联合贝前列素钠治疗幽门螺杆菌阴性慢性萎缩性胃炎疗效观察[J].转化医学杂志,2018,7(1):35-38,4.
