中国现代医生2018，Vol.56Issue(14)：14-17,4.
肝动脉化疗栓塞联合射频消融治疗原发性肝癌的疗效及对血清学指标的影响
Effectiveness of treatment combining hepatic arterial chemoembolization and radiofrequency ablation and its influence on serum markers in patients with primary liver cancer
摘要
Abstract
Objective To investigate the clinical effectiveness of treatment combining hepatic arterial chemoembolization (HACE) and radiofrequency ablation and its influence on serum markers in patients with primary liver cancer. Methods 50 patients with primary liver cancer in our hospital from January 2014 to January 2016 were selected and divided into observation group and control group. Patients in both of two groups were treated with HACE while patients in observation group were treated with additional radiofrequency ablation. Effectiveness of two groups was observed and compared. The levels of alpha fetoprotein (AFP), carbohydrate antigen 199 (CA199) and glutamyl transpeptidase (GGT) before and after treatment were detected. 2-year tumor-free survival and adverse reaction in two groups were observed. Results 4 weeks after treatment, levels of serum AFP, CA199 and GGT in two groups decreased significantly when compared with those before treatment(P＜0. 05 or P＜0. 0l) and those in observation group decreased more significantly(P＜0. 05). Total effective rate of treatment in observation group was higher than that in control group(P＜0. 05). The rate of 2-year tumor-free survival in observation group was higher than that in control group (P＜0. 05). The incidence of adverse reaction was not statistically different between two groups (P＞0. 05). Conclusion Treatment combining HACE and radiofrequency ablation in patients with primary live cancer was effective. It could reduce the levels of serum AFP, CA199 and GGT and improve the rate of 2-year tumor-free survival safely.关键词
原发性肝癌/肝动脉化疗栓塞/射频消融/血清学指标Key words
Primary liver cancer/Hepatic arterial chemoembolization/Radiofrequency ablation/Serum marker分类
医药卫生引用本文复制引用
张玉惠,张伟忠..肝动脉化疗栓塞联合射频消融治疗原发性肝癌的疗效及对血清学指标的影响[J].中国现代医生,2018,56(14):14-17,4.基金项目
浙江省科技计划项目(2015C33271) （2015C33271）
