中国现代医生2018，Vol.56Issue(14)：61-64,4.
宫颈上皮内瘤变Ⅱ/Ⅲ级与宫颈癌患者HPV感染基因型的分布差异分析
Analysis on the distribution difference of HPV genotypes in the patients with cervical intraepithelial neoplasia Ⅱ/Ⅲ and the patients with cervical cancer
摘要
Abstract
Objective To investigate the distribution differences of human papillomavirus(HPV) genotypes in the patients with cervical intraepithelial neoplasia grade Ⅱ/Ⅲ and the patients with cervical cancer. Methods 260 cases of cervical cancer and 280 cases of cervical intraepithelial neoplasia grade Ⅱ /Ⅲ patients who were admitted to our hospital from January 2010 to October 2017 were selected and divided into cancer group and neoplasia group respectively. The HPV infection of patients was detected and typing identification was performed. The distribution differences of HPV genotypes in cancer group and neoplasia group were compared. The differences of genotypes of HPV infection in different types of tissues in cancer group were also compared. Results The negative constituent ratio of HPV infection in cancer group was lower than that in neoplasia group(P＜0. 05), and the constituent ratio of all the high-risk types in single infection was significantly higher than that in the neoplasia group(P＜0. 05). The constituent ratio of all the low-risk types in single infection was significantly similar to that in the neoplasia group(P＞0. 05). The constituent ratio of multiple infections in cancer group was significantly higher than that in neoplasia group(P＜0. 05); the constituent ratios of negative HPV infections and 18 types of single infections in cervical squamous cell carcinoma was much lower than that of cervical adenocarcinoma(P＜0. 05). The constituent ratios of 16 types of HPV and multiple infections in cervical squamous cell carcinoma were much higher than that of cervical adenocarcinoma(P＜0. 05). Conclusion The risk of HPV infection in cervical cancer patients is significantly higher than that of cervical intraepithelial neoplasia grade Ⅱ /Ⅲ, the infection rate of cervical cancer high-risk type HPV is higher, and the risk of multiple infections is also higher. The tissue types of cervical cancer can be determined according to HPV typing.关键词
宫颈上皮内瘤变/宫颈癌/人乳头瘤病毒/基因型Key words
Cervical intraepithelial neoplasia/Cervical cancer/Human papillomavirus (HPV)/Genotypes分类
医药卫生引用本文复制引用
张晓兴,陈瑛瑛,王家建,朱凯..宫颈上皮内瘤变Ⅱ/Ⅲ级与宫颈癌患者HPV感染基因型的分布差异分析[J].中国现代医生,2018,56(14):61-64,4.基金项目
浙江省医药卫生科技计划项目(2018KY789) （2018KY789）
