中国现代医生2018，Vol.56Issue(14)：104-107,4.
rTMS刺激不同脑区联合帕罗西汀治疗强迫症的疗效研究
Curative effect of rTMS stimulation in different brain regions combined with paroxetine on the treatment of obsessive-compulsive disorder
摘要
Abstract
Objective To investigate the effects of rTMS stimulation in different brain regions combined with paroxetine on treating patients with obsessive -compulsive disorders. Methods Outpatients and inpatients with obsessive-compulsive disorder(OCD) treated at Kangning Hospital of Ningbo province from March 2015 to December 2016 were collected. Patients were randomly divided into control group(29 cases), treatment group 1(30 cases) and treatment group 2(30 cases). Patients in control group were treated with paroxetine only. Patients in treatment group 1 received rTMS stimulation of right prefrontal lobe combined with paroxetine systemic treatment. Patients in treatment group 2 received rTMS stimulation of bilateral supplementary motor area with paroxetine treatment. Obsessive -compulsive idea and behavior were assessed using Y-BOCS before treatment and 1, 2, 4, 6, 8 weeks after treatment. Adverse reaction was assessed after treatment with TESS. Results The Y-BOCS score of the control group decreased significantly at the 6th and the 8th week of treatment compared with before (P＜0. 05). The Y-BOCS score of the treatment group 1 and group 2 were significantly lower at 4, 6 and 8 weeks of treatment than that of the control group (P＜0. 05). The Y-BOCS scores of treatment group 1 and group 2 were significantly lower after 4 weeks of treatment than those before treatment (P＜0. 05). Conclusion rTMS stimulation of the right prefrontal lobe and bilateral supplementary motor area combined with paroxetine in the treatment of obsessive -compulsive disorder has consistent efficacy and take effect rapidly with minor adverse reactions.关键词
重复经颅磁刺激/强迫症/帕罗西汀/Yale-Brown强迫量表Key words
Repetitive transcranial magnetic stimulation/Obsessive-compulsive disorder/Paroxetine/Yale-Brown obsessive compulsive scale分类
医药卫生引用本文复制引用
刘纪猛,方泽忠,高树贵,禹海航,周东升..rTMS刺激不同脑区联合帕罗西汀治疗强迫症的疗效研究[J].中国现代医生,2018,56(14):104-107,4.基金项目
浙江省宁波市医学科技计划项目(2013A23) （2013A23）
浙江省宁波市自然科学基金(2013A610250) （2013A610250）
