中国现代医生2018，Vol.56Issue(15)：1-3,8,4.
低分子肝素对儿童脓毒症患者凝血功能及炎症因子的影响
Effect of low molecular weight heparin on blood coagulation and inflammatory factors in children with sepsis
摘要
Abstract
Objective To investigate the effect of low molecular weight heparin on coagulation and inflammatory factors in children with sepsis. Methods 78 children with sepsis admitted in our hospital from October 2013 to October 2017 were randomly divided into observation group and control group, each group had 34 cases. Children in the control group were given anti-infection, liquid resuscitation, nutritional support, treatment of primary disease and other basic treatment. The children in the observation group took the same treatment as the control group and injected 6000 Ulow molecular weight heparin subcutaneously once every 12 h for 7 d. Serum coagulation parameters (prothrombin time (PT), activated partial thromboplastin time(APTT), fibrinogen (FIB) and platelet (PLT)] and inflammatory factors [hypersensitivity Creaction (Hs-CRP), tumor necrosis factor(TNF-a)-alpha and interleukin(IL-6) levels were measured and compared. Results After 7 days of treatment, PT and APTT in both groups were significantly decreased, FIB and PLT were significantly increased(P＜0. 01 or P＜0. 05), and the decrease or increase in the observation group was more significant (P＜0. 05) The serum Hs-CRP, TNF-a and IL-6 index decreased significantly(P＜0. 01 or P＜0. 05), and the decrease rate of the observation group was more significant(P＜0. 05). The total clinical effective rate in the observation group was significantly higher than that in the control group (χ2=4. 20,P＜0. 05). Conclusion The treatment of low molecular weight heparin in children with sepsis shows better clinical therapeutic effect. It can not only correct the coagulation disorder, but also reduce the serum levels of Hs-CRP, TNF-a and IL-6 and control the inflammatory reaction more effectively.关键词
脓毒症/儿童/低分子肝素/凝血功能/炎症因子Key words
Sepsis/Children/Low molecular weight heparin/Coagulation/Inflammatory factor分类
医药卫生引用本文复制引用
姚桂爱,潜丽俊..低分子肝素对儿童脓毒症患者凝血功能及炎症因子的影响[J].中国现代医生,2018,56(15):1-3,8,4.基金项目
浙江省医药卫生科技计划项目(2016KYB337) （2016KYB337）
