中国现代医生2018，Vol.56Issue(15)：9-13,5.
绝经后女性类风湿关节炎患者骨密度的影响因素
Influencing factors of bone mineral density in postmenopausal women with rheumatoid arthritis
摘要
Abstract
Objective To explore the effects of activity and duration of RAand biological agents on bone mineral density. Methods From March 2013 to January 2016, 135 cases of postmenopausal women with RAwere selected and followed up for 1 year. Participants were divided into two groups according to whether they used bisphosphonates or not. Serum BGPand β-CTXof patients were detected. The disease activity index (DAS28 score, CDAI, SDAI) and HAQscore of RApatients were calculated. The bone mineral density(BMD) of lumbar vertebrae, femoral neck and total hip were measured by DEXA. Whether the patients were treated with biological agents was recorded. The relationship between variables and bone mineral density was analyzed by univariate and multivariate regression. Results Multiple linear regression analysis showed that there was a significant linear relationship between the course of disease and the bone mineral density of femoral neck and total hip. There was no significant correlation between the use of biological agents and bone mineral density. Conclusion Hip bone mineral density in postmenopausal women with RAis dependent on the course of disease, regardless of whether bisphosphonates are used or not. There was no significant correlation between the use of biological agents and bone loss.关键词
类风湿关节炎/骨质疏松/疾病活动度/双膦酸盐/生物制剂Key words
Rheumatoid arthritis/Osteoporosis/Disease activity/Bisphosphonates/Biological agents分类
医药卫生引用本文复制引用
李声东..绝经后女性类风湿关节炎患者骨密度的影响因素[J].中国现代医生,2018,56(15):9-13,5.基金项目
浙江省宁波市科技计划项目(2015A610179) （2015A610179）
