中国现代医生2018，Vol.56Issue(15)：14-17,21,5.
艾司洛尔联合早期目标导向治疗对重度脓毒症患者心肌功能的保护作用分析
Analysis on the protective effect of esmolol combined with early goal-directed therapy on myocardial function in the patients with severe sepsis
摘要
Abstract
Objective To analyze the protective effect of esmolol combined with early goal-directed therapy on myocardial function in patients with severe sepsis. Methods The clinical data of patients with severe sepsis who were treated in our hospital were retrospectively analyzed. According to the principles of randomization, balance and control, 30 cases receiving esmolol combined with early goal-directed therapy were selected as the observation group. The other 30 cases who were given early goal-directed therapy during the same period were selected as the control group. The effects of the two treatment regimens on the levels of hemodynamic indices, cTnT, BNP, TNF-a, IL-1β, Lac, central venous oxygen saturation(ScvO2) and other indices were compared, and 28-day survival rate was statistically analyzed. Results After treatment, Ea/Aa in the observation group was increased significantly, and HRwas decreased significantly. Only HRwas decreased significantly in the control group. There was no statistically significant difference within groups and between the two groups in other hemodynamic indices (P＞0. 05); the levels of cTnT, BNP, TNF-a, and IL-1β in both groups were significantly decreased and the observation group was lower than the control group. The differences within groups and between groups were statistically significant; the serum Lac was decreased and ScvO2 was increased in both groups. The serum Lac in the observation group was lower than that in the control group, and ScvO2 was higher than that in the control group. There were statistically significant differences within groups and between groups (P＜0. 05); the survival rate in the observation group was slightly higher than that in the control group, but the difference was not statistically significant(χ2=0. 480, P=0. 488). Conclusion Esmolol combined with early goal-directed therapy may benefit myocardial protection in patients with severe sepsis.关键词
艾司洛尔/早期目标导向治疗/严重脓毒症/心肌功能/保护作用Key words
Esmolol/Early goal-directed therapy/Severe sepsis/Myocardical function/Protective function分类
医药卫生引用本文复制引用
黄道超,秦杰,单仁飞,蒋永泼,徐安忆,管琼婵..艾司洛尔联合早期目标导向治疗对重度脓毒症患者心肌功能的保护作用分析[J].中国现代医生,2018,56(15):14-17,21,5.基金项目
浙江省医药卫生科技计划项目(2017KY706) （2017KY706）
