中国现代中药2018，Vol.20Issue(1)：20-25,28,7.DOI:10.13313/j.issn.1673-4890.20170827002
美洲大蠊的含氮成分及其促创面愈合相关活性研究
Nitrogen Containing Chemical Constituents from Periplaneta americana and Their Wound-healing Promoting Activities
摘要
Abstract
Objective: To explore compounds from Periplaneta americana and investigate their wound-healing promoting activities. Methods: Small molecules were isolated by using column chromatography and their structures were identified by spectroscopic methods. Results: Sixteen compounds isolated from P. americana were identified as 2-(1,2,3-trihydroxypropyl)pyrazine (1), 2-methyl-6-(2, 3,4-trihydroxybutyl)pyrazine (2), 3-methyl-6-(2, 3, 4-trihydroxybutyl)pyrazine (3), 3-hydroxypyridine (4), 1-(2-hydroxyethyl)-5-(hydroxymethyl)-1 H-pyrrole-2-carbaldehyde (5), N-(5-acetylpyrrol-3-yl)acetamide (6), 8-hydroxy-2, 3-dihydro-4 (1H)-quinolone (7), valerolactam (8),N-acetyldopamine (9), aspongopusin (10), deoxyhyrtiosine A (11), lumichrome (12), 6-hydroxymethyl-3-pyridinol (13), 3, 4-dihydroxyphenylglycol (14), 2-(isopentyl) phenol (15), and 5- (hydroxymethyl) furan-2-carbaldehyde (16),respectively. Conclusion: Compounds 1,3,5,and 6 are new naturally occurring compounds,and compounds 2,4, 7, 10-16 were isolated from the title insect species for the first time. Biological evaluation revealed that compounds 12-14 could significantly stimulate HDFs migration with 13 to be the most active. In addition, compound 3 was found to be active towards HUVECs angiogenesis.关键词
美洲大蠊/含氮成分/创面愈合Key words
Periplaneta americana/nitrogen containing compounds/wound-healing activities引用本文复制引用
王心龙,向斌,李亚美,秦付营,耿福能,晏永明,程永现..美洲大蠊的含氮成分及其促创面愈合相关活性研究[J].中国现代中药,2018,20(1):20-25,28,7.基金项目
深圳市科技计划项目(JCYJ20170412110504956) （JCYJ20170412110504956）
国家自然基金面上项目(81773606) （81773606）
