摘要
Abstract
Objective: To investigate the characteristics and regularities of adverse drug reactions (ADR) in a children's hospital in recent years, so as to provide basis and reference for rational and safety medication and reduction of ADR. Methods: Retrospective method was adopted, totaly 414 ADR reports were collected from a children's hospital during 2014 to 2016. Statistical analysis was conducted on children's gender, age, suspicious drugs, route of administration, dosage form, systems and organs involved in ADR, relevance evaluation and prognosis. Results: Among the 414 ADR reports, the gender ratio of male to female was 2 ∶ 1, the age was (3.09±0.11) years old. The incidence of ADR was the highest in children of 1 to 3 years old (57.49％), the age group of 4 to 7 years was lower (31.88％), the incidence of neonate group was much lower than those of the other two groups ( 6.76％) . Intravenous drip administration was the main route (95.41％), involving 12 categories of drugs, among them, the top 3 drug categories that caused ADR were respectively antibiotics ( 46.16％), Chinese patent medicine ( 30.77％) and antiviral drugs ( 15.38％) . Four hundreds and fourteen cases of ADR involved multiple systems and organs, totally 488 frequencies; the clinical manifestations were mainly performed as skin and its accessories damage ( 400 frequencies, 81.97％), followed by systemic damage and cardiovascular system generally damage ( 19 frequencies, 3.89％, respectively) ; and gastrointestinal system damage ( 16 frequencies, 3.28％) dominated the forth place. Conclusion: More precautions should be taken against children's medication risks, and various measures should be taken to promote children's rational and safe medication, so as to minimize and avoid the occurrence of ADR.关键词
儿童/药品不良反应/分析Key words
children/adverse drug reactions/analysis分类
医药卫生
