世界中医药2018，Vol.13Issue(8)：1929-1932,4.DOI:10.3969/j.issn.1673-7202.2018.08.027
葛根素注射液治疗糖尿病周围神经病变的疗效及对肌电图、血液流变学的影响
Clinical Efficacy of Puerarin Injection in the Treatment of Diabetic Peripheral Neuropathy and the Influence on Electromyogram and Hemorheology
摘要
Abstract
Objective: To explore the clinical efficacy of puerarin injection in the treatment of diabetic peripheral neuropathy ( DPN) and the influence on electromyogram and hemorheology.Methods:A total of 96 cases of DPN patients from November 2014 to February 2017 were selected and randomly divided into observation group ( n＝48) and control group ( n＝48).The control group was treated by α-lipoic acid with limited diet and hypoglycemic agents by or administration.The observation group was trea-ted with puerarin injection on the basis of treatment in the control group.Both groups were treated for 2 months continuously.Com-parison was made on the clinical efficacy ,the symptom scores of peripheral neuropathy (TSS) and the change of electromyogram and hemorheology in 2 groups before and after treatment.Results:The total effective rate was 91.67%in observation group,which was significantly higher than 81.25%in control group (P＜0.05).Compared with the scores before the treatment ,the TSS scores including numbness,tingling,cramps,weakness,and the HSV,LSV,PSV,HCT as well as platelet aggregation rate of 2 groups were significantly decreased after the treatment (P＜0.05 or P＜0.01).And the observation group was evidently lower than the control group (P＜0.01).Compared with statics before the treatment ,the MNCV,SNCV of median nerve and common peroneal nerve of 2 groups were obviously increased after the treatment ,and the observation group was evidently higher than the control group ( P＜0.01).Conclusion:In the treatment of DPN,puerarin injection can significantly relief the clinical symptoms of patients ,improve the electromyogram and hemorheology ,and the clinical efficacy is better than western medicine alone.关键词
糖尿病/周围神经病变/葛根素注射液/疗效/肌电图/血液流变学Key words
Diabetic peripheral neuropathy/Puerarin injection/Clinical efficacy/Electromyogram/Hemorheology分类
医药卫生引用本文复制引用
王凌霄,温宏峰,才丽娜,李文雅..葛根素注射液治疗糖尿病周围神经病变的疗效及对肌电图、血液流变学的影响[J].世界中医药,2018,13(8):1929-1932,4.基金项目
2017首都临床特色应用研究( z171100001017137) （ z171100001017137）
