世界中医药2018，Vol.13Issue(8)：2032-2035,4.DOI:10.3969/j.issn.1673-7202.2018.08.050
发酵虫草菌粉多糖免疫活性实验研究
Experimental Study on Immune Activities of Polysaccharides from Fermented Cordycepssinensis Powders
蒋洪亮 1赵修南 2麻浩 2何丽芳 3单俊杰 2王海南1
作者信息
- 1. 贵州大学药学院,贵阳,550025
- 2. 军事科学院军事医学研究院,北京,100850
- 3. 湖南中医药大学,长沙,410208
- 折叠
摘要
Abstract
Objective:To investigate the immunological activity of polysaccharides from fermented Cordycepssinensis powders . Methods:Polysaccharides from fermented Cordycepssinensis powders were obtained through water extraction and alcohol precipita -tion,reconstitution,dialysis,concentration and freeze-drying,named after CSMP-60.Its extraction conditions:60 ℃ water extrac-tion,extraction time 4h,solid-liquid ratio 1∶15,the number of extractions 2 times.The immune activity of CSMP-60 was measured using mouse immune cells.Results:CSMP-60 could promote the proliferation of spleen cells (P＜0.05),and significantly promote the secretion of TNF-αfrom mouse peritoneal macrophages ( P＜0.05).It has a tendency to promote the secretion of IFN-γby spleen cells.Conclusion:CSMP-60 may be one of the immunocompetence substances of fermented Cordycepssinensis powders .关键词
发酵虫草菌粉/多糖/细胞增殖/脾细胞/巨噬细胞/免疫活性/肿瘤坏死因子/γ-干扰素Key words
Fermented Cordycepssinensis powders/Polysaccharides/Cell proliferation/Spleen cells/Macrophages/Immune ac-tivity/TNF-α/IFN-γ分类
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蒋洪亮,赵修南,麻浩,何丽芳,单俊杰,王海南..发酵虫草菌粉多糖免疫活性实验研究[J].世界中医药,2018,13(8):2032-2035,4.
