生命科学研究2018，Vol.22Issue(2)：143-148,6.DOI:10.16605/j.cnki.1007-7847.2018.02.008
广州地区中老年男性RANK/RANKL/OPG和WNT信号通路基因多态性与髋部骨强度的关联分析
Association of Genes in RANK/RANKL/OPG and WNT Signaling Pathways with Hip Bone Strength among Middle-Aged and Elderly Males in Guangzhou
摘要
Abstract
The association of genes in the RANK/RANKL/OPG and WNT signaling pathways with hip bone strength was investigated among the middle-aged and elderly males. A total of 788 males aged over 40 years were included in the study. They were recruited from Guangzhou, China. Ten single nucleotide polymorphisms in 6 genes were genotyped using MassArray. Bone mineral density (BMD), cross-sectional area (CSA), average cortical thickness (ACT), section modulus (SM) and buckling ratio (BR) at the femoral neck were mea-sured by dual-energy X-ray absorptiometry. The relationships between the genes and bone phenotypes were detected using multiple linear regression analysis. The results showed that the minor allele C of rs3134069 in OPG gene was negatively associated with BMD and ACT(β =-0.017,P=0.024 for BMD;β=-0.004, P=0.040 for ACT). In the LRP5 gene, the minor allele T of rs3736228 was related with the lower BMD, CSA, ACT(β=-0.050～-0.003, P<0.050) and higher BR (β=0.242, P=0.043), and the minor allele G of rs491347 was associ-ated with the reduction of BMD (β=-0.012, P=0.046). This study supported that the OPG and LRP5 genes were associated with hip bone strength of the middle-aged and elderly males in Guangzhou.关键词
RANK/RANKL/OPG信号通路/WNT信号通路/基因多态性/髋部骨密度/髋部骨几何结构Key words
RANK/RANKL/OPG signaling pathway/WNT signaling pathway/polymorphism/hip bone mineral density/hip geometric structure分类
医药卫生引用本文复制引用
王希丹,肖苏妹,陈裕明..广州地区中老年男性RANK/RANKL/OPG和WNT信号通路基因多态性与髋部骨强度的关联分析[J].生命科学研究,2018,22(2):143-148,6.基金项目
国家自然科学基金资助项目(81273049,81400857) （81273049,81400857）
广东省自然科学基金资助项目(2014A030313132) （2014A030313132）
广州市科技计划项目(201610010093) （201610010093）
中山大学5010临床研究项目(2007032) （2007032）
