生命科学研究2018，Vol.22Issue(2)：149-157,9.DOI:10.16605/j.cnki.1007-7847.2018.02.009
秀丽隐杆线虫在神经退行性疾病研究中的应用
Application of Caenorhabditis elegans in Study of Neurodegenerative Diseases
摘要
Abstract
Neurodegenerative diseases (NDs) are diseases caused by loss of neurons or myelin sheaths in the brain or spinal cord. Elderly population has a high risk of developing NDs, and the symptoms of NDs progress rapidly within years. The diseases will bring huge impacts on these patients physically and mentally, and meanwhile, impose additional charges on their families. In recent years, more and more researchers have focused on NDs. Multiple model systems, particularly Caenorhabditis elegans, have been applied to look for pathogenic factors as well as effective treatments of NDs. This article aims to review the application of C. elegans in studies of Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral scle-rosis (ALS), including the identification of causes of these diseases, the advantages of ND model of C. elegans and the application of C. elegans in potential drug screening for NDs.关键词
神经退行性疾病(NDs)/阿尔茨海默病(AD)/帕金森病(PD)/肌萎缩侧索硬化(ALS)/模式动物/秀丽隐杆线虫Key words
neurodegenerative diseases (NDs)/Alzheimer's disease (AD)/Parkinson's disease (PD)/amyotrophic lateral sclerosis (ALS)/model animal/Caenorhabditis elegans分类
生物科学引用本文复制引用
凌伟,王雅丽,吴德玲,王桐生,张伟,梁德勤,李正,许双旺..秀丽隐杆线虫在神经退行性疾病研究中的应用[J].生命科学研究,2018,22(2):149-157,9.基金项目
国家自然科学基金资助项目(81373841) （81373841）
