生命科学研究2018，Vol.22Issue(2)：158-166,9.DOI:10.16605/j.cnki.1007-7847.2018.02.010
靶向调控Nrf2-ARE通路的miRNAs研究进展
The Advance of miRNAs in Nrf2-ARE Pathway
摘要
Abstract
The imbalance between production and removal of reactive oxygen species (ROS) in the body is an important factor leading to in vivo pathological changes. Previous studies have shown that multiple signaling pathways are involved in mediating the balance of ROS formation and degradation in the living organisms. Among these pathways, the nuclear factor erythroid 2 related factor 2-antioxidant responsive element (Nrf2-ARE) pathway plays a very important role in cytoprotective action through inducing the expression of antioxidant enzymes and scavenging excess ROS. Therefore, it is also the focus of current research to elucidate the molecular mechanisms of activation or inactivation of this pathway. MicroRNAs (miRNAs) are a group of very small and non-coding RNA molecule found widely in eukaryotes, which function in regulating gene expres-sion. It has been found that a variety of miRNAs can target key molecules in the Nrf2-ARE signaling path-way and regulate their expression, and therefore participate in the activation and inactivation of the signaling pathway. Current report shows that miRNAs play a significant role in the maintenance of redox homeostasis. Summarizing the recent research progress of miRNAs in regulating Nrf2-ARE pathway helps further clarify the role of this pathway in the process of the body,s redox reaction.关键词
活性氧类(ROS)/Nrf2-ARE通路/核因子E2相关因子2(Nrf2)/Kelch样ECH相关蛋白1 (Keapl)/miR-NAs/氧化还原稳态Key words
reactive oxygen species (ROS)/Nrf2-ARE pathway/the nuclear factor erythroid 2 related factor 2 (Nrf2)/kelch-like ECH-associated protein 1 (Keapl)/miRNAs/redox homeostasis分类
医药卫生引用本文复制引用
郑皖,冯湘玲,杨飞,陈继华..靶向调控Nrf2-ARE通路的miRNAs研究进展[J].生命科学研究,2018,22(2):158-166,9.基金项目
国家自然科学基金资助项目(81472972,81502787) （81472972,81502787）
湖南省自然科学基金资助项目(2017JJ2401) （2017JJ2401）
