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SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes

Min-Zhe Li Liang-Jun Zheng Jian Shen Xin-Ya Li Qi Zhang Xue Bai Qing-Song Wang Jian-Guo Ji

中国神经再生研究（英文版）2018，Vol.13Issue(11)：2005-2013,9.

中国神经再生研究（英文版）2018，Vol.13Issue(11)：2005-2013,9.DOI:10.4103/1673-5374.239449

SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes

Min-Zhe Li ¹Liang-Jun Zheng ²Jian Shen ¹Xin-Ya Li ²Qi Zhang ²Xue Bai ²Qing-Song Wang ²Jian-Guo Ji²

作者信息

1. General Surgery Department, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
2. State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China
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摘要

关键词

nerve regeneration/amyloid beta peptide/Alzheimer's disease/neurodegeneration/astrocytes/gliocytes/sirtuin1/quantitative proteomics/lysosome/time point model/peptide degradation/neural regeneration

Key words

引用本文复制引用

Min-Zhe Li,Liang-Jun Zheng,Jian Shen,Xin-Ya Li,Qi Zhang,Xue Bai,Qing-Song Wang,Jian-Guo Ji..SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes[J].中国神经再生研究（英文版）,2018,13(11):2005-2013,9.

基金项目

This study was supported by the National Natural Science Foundation of China, No. 31670832, 31470807, 31270872 （）

a grant from the National Key Research and Development Program of China, No. 2016YFA0500301 （）

and a grant from the State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, China. （）

中国神经再生研究（英文版）

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ISSN：1673-5374

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