中国药理学通报2018，Vol.34Issue(9)：1189-1192,4.DOI:10.3969/j.issn.1001-1978.2018.09.002
靶向survivin克服肿瘤耐药的研究进展
New strategy for antagonizing drug resistance: targeting survivin
摘要
Abstract
Multidrug resistance ( MDR) often leads to failure of cancer chemotherapy. survivin, a member of the inhibitor of apoptosis proteins (IAP) family, is overexpressed in almost all kinds of tumor cells. Importantly, survivin has been identified as one of the most important molecules involved in the regulation of MDR. Therefore, inhibiting the activity of survivin or down-reg-ulating the expression of survivin might be an effective strategy to overcome tumor MDR. In this article, the roles of survivin in-volved in the development of drug resistance and the strategies to overcome drug resistance by targeting survivin are thus re-viewed.关键词
肿瘤/化疗/多药耐药/survivin/凋亡抑制蛋白家族/靶向Key words
tumor/chemotherapy/multidrug resistance/sur-vivin/inhibitor of apoptosis proteins (IAP) family/targeting分类
医药卫生引用本文复制引用
吴华国,张慧..靶向survivin克服肿瘤耐药的研究进展[J].中国药理学通报,2018,34(9):1189-1192,4.基金项目
自然科学基金资助项目( No 8150111724) （ No 8150111724）
山东省博士基金资助项目(No 2015BSC03007) （No 2015BSC03007）
山东省医科院基金资助项目(No 2014-42) （No 2014-42）
