中国药理学通报2018，Vol.34Issue(9)：1193-1198,6.DOI:10.3969/j.issn.1001-1978.2018.09.003
基因多态性对类风湿关节炎药物疗效和不良反应影响的研究进展
Advances of gene polymorphism affecting rheumatoid arthritis drug efficacy and adverse drug reactions
摘要
Abstract
Drugs for the treatment of rheumatoid arthritis ( RA) include disease-modifying antirheumatic drugs ( DMARDs ), nonsteroidal anti-inflammatory drugs ( NSAIDs) and biological agents, etc. These drugs are critical in preventing the process and complications of RA. However, the outcome of treatment and adverse drug reactions with these drugs in RA patients are different individually. Drug-metabolizing enzymes (dihydrofolate reductase, cytochrome P450enzymes, N-acetyltransferases, and so on. ), drug transporters ( ATP-binding cassette transporters) and drug targets ( tumor necrosis factor-α receptors) are coded for by variant alleles. The gene polymorphism of drug transport-ers can change the distribution and excretion of drugs. The poly-morphisms of drug target affect significantly drug sensitivity. These gene polymorphisms may influence the pharmacokinetics, pharmacodynamics and side effects of medicine. In this article, we review the genetic polymorphisms that affect the efficacy of drug or the occurrence of adverse drug reactions in RA.关键词
基因多态性/类风湿关节炎/药物/代谢/疗效/不良反应Key words
gene polymorphism/rheumatoid arthritis/drugs/metabolism/efficacy/adverse reactions分类
医药卫生引用本文复制引用
张贤政,邰宇,张玲玲,魏伟..基因多态性对类风湿关节炎药物疗效和不良反应影响的研究进展[J].中国药理学通报,2018,34(9):1193-1198,6.基金项目
国家自然科学基金资助项目( No 81330081, 81473223, 81673444) （ No 81330081, 81473223, 81673444）
