中国药理学通报2018，Vol.34Issue(9)：1199-1202,4.DOI:10.3969/j.issn.1001-1978.2018.09.004
感染加重慢性呼吸道疾病的小鼠模型研究进展
Murine models of infectious exacerbation of respiratory disease
摘要
Abstract
Asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis(CF) lung disease are common chronic respiratory diseases. There has been evidence that respiratory in-fections with bacteria and viruses underpin the pathogenesis of the respiratory diseases. It is now well-recognized that early life infections may induce more severe asthma by inducing permanent alterations in immunity and lung structure, and even induce ster-oid-resistant severe asthma in adulthood. Respiratory infections will exacerbate the inflammation and remodeling in lung of COPD. P. aeruginosa infection in lung will induce CF. There are no effective therapies preventing or reversing the exacerbation of respiratory diseases. The development and use of mouse mod-els are proved to be valuable in understanding the role of infec-tion in disease pathogenesis. This article reviews the progresses in murine models of infectious exacerbation of respiratory disea-ses, emphasizes on the pathological changes of the three respira-tory diseases found with the application of murine models, and explores the therapeutic method which can be developed and tested by the application of murine models, in order to offer ref-erence for clinical research and treatment.关键词
哮喘/慢性阻塞性肺病/肺部囊性纤维化/细菌/病毒/小鼠模型Key words
asthma/chronic obstructive pulmonary disease/cystic fibrosis/bacteria/virus/murine models分类
医药卫生引用本文复制引用
张国荣,刘楠,徐洋,刘莉..感染加重慢性呼吸道疾病的小鼠模型研究进展[J].中国药理学通报,2018,34(9):1199-1202,4.基金项目
上海市生物物质成药性评价专业技术服务平台( No 15DZ2291700) （ No 15DZ2291700）
