生命科学研究2018，Vol.22Issue(4)：326-331,6.DOI:10.16605/j.cnki.1007-7847.2018.04.010
外泌体在肿瘤侵袭转移中作用的研究进展
Progress of Exosomes in Tumor Metastases
摘要
Abstract
Exosome, a kind of 40～100 nm particle enclosed by a phospholipid bilayer, is released by various types of cells. Exosome is composed of liposomes, proteins, DNA, mi RNA and so on. A number of studies have revealed that exosomes are involved in many important physiological and pathological processes especially in the metastasis of tumors by carrying biomolecules. Exosomes play an important role in the metastasis of tumors via initiating the metastasis of tumors, promoting tumor angiogenesis, participating in the regulation of tumor premetastatic microenvironment and the immune regulation of tumor microenvironment.关键词
外泌体/肿瘤转移/上皮间质转化/血管生成/肿瘤微环境/免疫逃逸Key words
exosome/tumor metastasis/epithelial-mesenchymal transition/angiogenesis/tumor microenvironment/immune escape分类
生物科学引用本文复制引用
宋丽杰,王丽,王捷..外泌体在肿瘤侵袭转移中作用的研究进展[J].生命科学研究,2018,22(4):326-331,6.基金项目
国家自然科学基金青年科学基金项目(81402409) （81402409）
广东省自然科学基金资助项目(2015A03031313605) （2015A03031313605）
广东省医学科学技术研究基金项目(B2018144) （B2018144）
