生命科学研究2018，Vol.22Issue(4)：338-344,7.DOI:10.16605/j.cnki.1007-7847.2018.04.012
抗菌肽鲎素的研究进展
Research Progresses on Antimicrobial Peptide Tachyplesins
摘要
Abstract
Antibacterial peptides tachyplesins (TPs), isolated from the hemocytes of horseshoe crabs and divid-ed into five kinds, play an important role in immunological function in the limulus immune system and pro-vide a natural defense barrier for the invasion of pathogens. Nearly 30 years of research shows that TPs ex-hibit broad-spectrum bioactivities, low cytotoxicity toward normal cells, and low levels of acquired resistance in microbes. As an entirely new type of peptide drug, TPs have become an intensely studied topic. Herein, the molecular structure of TPs, bioactivity against all kinds of microorganisms and tumor cells, action mech-anisms and engineering expression are introduced. The application and the bottleneck of current research of TPs are also described.关键词
抗菌肽鲎素(TPs)/生物活性/作用机制/基因工程/应用/瓶颈Key words
tachyplesins (TPs)/bioactivity/mechanism of action/gene engineering/application/bottleneck分类
生物科学引用本文复制引用
李寒梅,唐勇军,王顺启,代建国..抗菌肽鲎素的研究进展[J].生命科学研究,2018,22(4):338-344,7.基金项目
广东省自然科学基础研究重大项目(2017GKZDXM011) （2017GKZDXM011）
广东省高校高层次人才项目(20132011) （20132011）
国家自然科学基金地区科学基金资助项目(31460260) （31460260）
