中国中西医结合杂志2018，Vol.38Issue(8)：927-931,5.DOI:10.7661/j.cjim.20180623.182
香砂六君汤加减联合甲羟孕酮治疗肿瘤食欲不振—恶病质综合征临床研究
Clinical Research on Modified Xiangsha Liujun Decoction Combined with Medroxyprogesterone in Treating Cancer-related Anorexia and Cachexia Syndrome
摘要
Abstract
Objective To observe the clinical efficacy of modified Xiangsha Liujun Decoction combined with medroxyprogesterone in treating cancer-related anorexia and cachexia syndrome (CACS) .Methods Totally90 patients were randomly assigned to the Western medicine (WM) group, the Chinese medicine (CM) group and the combined group, 30 cases in each group.Patients in WM group received medroxyprogesterone, those in the CM group took modified Xiangsha Liujun Decoction, and those in the combined group took modified Xiangsha Liujun Decoction and medroxyprogesterone.The therapeutic course for all was 8 weeks.The Karnofsky performance scale (KPS) score, Quality of Life (QOL) score, appetite were observed before and after treatment, and median survival time was analyzed.Results Thirty cases dropped out in the process.Eifficacy could be assessed in60 cases, 20 in each group.Compared with the WM group, there was no obvious changes in KPS score, QOL score and appetite after treatment in the CM group (P＞0.05) .After treatment the KPS score, QOL score and appetite improved more obviously in the combined group than the WM group and CM group (P＜0.05) .The median survival time was 5 months (95％CI:4.526-5.474) in the WM group, 6 months (95％CI:5.164-6.836) in the CM group, 9 months (95％CI:7.569-10.431) in the combined group.Compared with the WM group and the CM group, the median survival time was longer in the combined group (P=0.042) .Conclusions Xiangsha Liujun Decoction combined with medroxyprogesterone could improve appetite, KS score, QOL score and the median survival time of patients with CACS.关键词
香砂六君汤加减/甲羟孕酮/肿瘤食欲不振—恶病质综合征/脾胃虚弱证Key words
Modified Xiangsha Liujun Decoction/medroxyprogesterone/cancer-related anorexia and cachexia syndrome/Pi-wei weakness syndrome引用本文复制引用
王鹂,邹玺,刘沈林..香砂六君汤加减联合甲羟孕酮治疗肿瘤食欲不振—恶病质综合征临床研究[J].中国中西医结合杂志,2018,38(8):927-931,5.基金项目
江苏省高校优势学科(No.BL2014100) （No.BL2014100）
江苏省中医药管理局课题(No.YX1208) （No.YX1208）
