中国中西医结合杂志2018，Vol.38Issue(8)：1006-1010,5.DOI:10.7661/j.cjim.20180412.015
基于网络药理学方法的雷公藤药理、毒理机制研究
Based on Network Pharmacological Approaches to Re-study the Pharmacology and Toxicity Mechanism of Tripterygium Wilfordii Hook F.
摘要
Abstract
Objective Using network pharmacology methods, the pharmacological and toxicological mechanisms of Tripterygium Wilfordii Hook F.were restudied for providing some new data and research strategy on its development and application.Methods The protein-protein interaction networks of drug targets, the on-target and off-target related networks were built by using some online database (SinoMed, Polysearch, DrugBank, David etc.) .The biological information, pathways, and functions were obtained by network analysis.Results Besides anti-rheumatoid, the active pharmaceutical ingredients of Tripterygium Wilfordii Hook F.showed anti-tumor, anti-oxidation.The on-target effect of Tripterygium Wilfordii Hook F.was related to regulate immune function.Taking part in process of cell proliferation, apoptosis and inflammation, the off-target effect of Tripterygium Wilfordii Hook F.has been indirectly suggesting the relationship with its side effects.Conclusions The network pharmacology method explores the connection between the existing knowledge of Tripterygium Wilfordii from the system and nonlinear levels, and analyzes the relationship between the corresponding targets and the direct-action model to reveal the potential anti-tumor and anti-oxidation activities for their corresponding molecules.The study of network pharmacological provides a new mechanism research direction.关键词
网络药理学/雷公藤/药理/毒理Key words
network pharmacology/Tripterygium Wilfordii Hook F./pharmacology/toxicity引用本文复制引用
许可嘉,赵雨坤,顾灏,张弛,吕爱平,李健..基于网络药理学方法的雷公藤药理、毒理机制研究[J].中国中西医结合杂志,2018,38(8):1006-1010,5.基金项目
国家自然科学基金资助项目(No.81273884,No.8150141694) （No.81273884,No.8150141694）
