中国输血杂志2018，Vol.31Issue(6)：634-636,3.DOI:10.13303/j.cjbt.issn.1004-549x.2018.06.016
A2型急性髓系白血病患者血型鉴定及输血策略研究——附1例报道
Blood type identification and corresponding transfusion strategy of patients with type M2 A2 leukemia
刘于嵩 1宋建 1岑宜静 1赵鹃 1邱发麒2
作者信息
- 1. 四川省医学科学院 四川省人民医院东院 检验科,四川 成都 610100
- 2. 四川省医学科学院 四川省人民医院东院 血液科,四川 成都 610100
- 折叠
摘要
Abstract
Objective ABO type identification of patients with type M2 A2 leukemia was carried out to avoid potential errors caused by the disease. A patient-specific transfusion strategy of red blood cells (RBCs) and platelets was proposed to improve transfusion efficacy and safety.Methods Serological and molecular biology tests were conducted on 1 case of type M2 leukemia patient with inconsistent forward-reverse ABO typing results. Serological methods were used to identify valid suspended RBC source and platelet supply for the patient. Results According to the results of serological and molecular biology tests, the patients were identified as A2 subtype and genotype A02/O01. The irregular antibody screening test showed negative, and A1 cells antibodies were detected in the plasma. A total of 32 transfusion treatments were made, including 16 treatments of washed type O transfusions (2 U per treatment) and 16 treatments of type A platelet (1 U per treatment). Clinical data and patient recovery status confirmed desired therapeutic effect. No adverse reaction occurred such as chills, fever, etc. No anti-A1 antibody was detected during the later stage of the treatment. Conclusion The inconsistent forward-reverse ABO typing results were not associated with the disease. Chemotherapy did reduce antibody content in the blood. Type A platelet and type O washed RBC transfusion for this patient met the desired clinical requirement of the treatment. When encountering inconsistent ABO typing results, serological and molecular biology methods ought to be used for refined confirmation of the patient condition. For patients with ABO typing issues potentially caused by blood diseases, transfusion ought to be performed under the strictest standard possible to ensure transfusion effect and safety. Unexpected antibody reactions need to be taken into consideration to ensure effective treatment throughout.关键词
ABO血型/A2亚型/血型鉴定/输血Key words
ABO blood group/A2 subtype/blood type identification/transfusion分类
医药卫生引用本文复制引用
刘于嵩,宋建,岑宜静,赵鹃,邱发麒..A2型急性髓系白血病患者血型鉴定及输血策略研究——附1例报道[J].中国输血杂志,2018,31(6):634-636,3.
