中国中西医结合杂志2018，Vol.37Issue(11)：1297-1300,4.DOI:10.7661/j.cjim.20170925.225
知柏地黄丸对糖尿病前期阴虚燥热证人群干预的临床研究
Clinical Study on Intervention of Zhibai Dihuang Pill on Pre-diabetic Patients with Yin Deficiency and Dryness-heat Syndrome
摘要
Abstract
Objective To observe the clinical effect of Zhibai Dihuang Pill(ZBDHP) on pre-diabetic with yin deficiency and dryness-heat syndrome. Methods Totally 260 cases diagnosed as pre-diabetic patients with yin deficiency and dryness-heat syndrome were randomly assigned to the treatment group with ZBDHP (130 cases) and the control group (130 cases). After observation, 39 cases were dropped out or rejected, 108 cases in the treatment group and 113 cases in the control group were counted. The patients in the two groups were involved in healthy education and general lifestyle intervention, meanwhile the treatment group additionally took ZBDHP, 8 pills, 2 times per day. After 12 months treatment, the weight (Wt),body mass index (BMI),waist circumference (Wc), fasting plasma glucose(FPG),75 g oral glucose after 2 hours blood glucose (2h PG),glycosylated hemoglobin A1 c (HbA1 c), triglyceride (TG), total cholesterol (TC),traditional Chinese medicine (TCM) symptom score were detected. The diabetic conversion rate,normal blood glucose conversion rate and impaired glucose regulation ( IGR) stable rate were calculated. Results Compared with the control group, the diabetic conversion rate of the treatment group decreased (P ＜ 0. 01 ), and the IGR stable rate increased (P ＜ 0. 05 ). There was no significant difference between the two groups in the normal blood glucose conversion rate(P ＞0. 05). The levels of FPG, 2h PG, HbA1c, TG, TC,Wt, BMI,Wc and TCM symptom score of the two groups were decreased after treatment than those before treatment (P ＜0. 05,P ＜0. 01). Compared with the control group, the levels of FPG, 2h PG,HbA1c,TG,Wc and TCM symptom score of the treatment group decreased(P ＜0. 05,P ＜0. 01). There were no significant difference in liver and kidney function and electrocardiogram between the two groups before and after treatment (P ＞0. 05). Conclusions ZBDHP can reduce the levels of FPG, 2h PG, HbA1c, TG, Wc,and relieve the clinical symptoms in the pre-diabetic patients with yin deficiency and dryness-heat syndrome, delay the onset of diabetes.关键词
糖尿病前期/知柏地黄丸/生活方式干预/阴虚燥热证Key words
pre-diabetic/Zhibai Dihuang Pill/lifestyle intervention/yin deficiency and dryness-heat syndrome引用本文复制引用
龚敏,刘蔚,邹丽妍,白春英,周淑君..知柏地黄丸对糖尿病前期阴虚燥热证人群干预的临床研究[J].中国中西医结合杂志,2018,37(11):1297-1300,4.基金项目
青岛市卫生局2012年度中医科研计划项目(No. 2012 -zyz002) （No. 2012 -zyz002）
