中国中西医结合杂志2018，Vol.37Issue(11)：1305-1309,5.DOI:10.7661/j.cjim.20171011.237
获得性免疫缺陷综合征患者中医体质对CD4 + T淋巴细胞及其亚群的影响
Effect of Chinese Medical Constitution on CD4 + T Lymphocyte and It's Subsets in HIV/AIDS Patients
摘要
Abstract
Objective To explore the correlation between Chinese medical constitution and CD4 + T lymphocyte and it's subsets,according to summarize and analyze the clinical data of 54 patients with HIV/AIDS. Methods The data of HIV/AIDS patients treated in infectious diseases clinic and ward of Nantong third hospital affiliated to Nantong University from August 2014 to January 2016 were collected and analyzed. The constitution of Chinese medicine was observed and the CD4 +T lymphocyte and its subgroups in different constitutions were detected. Results Among the 54 cases, 35 cases(64. 81 ％ ) were facultative constitution, 12 cases (22. 22％ ) were single constitution, and the other 7 cases (12. 96％ ) were mild constitution. Qi deficiency (23 times), Yang deficiency (15 times ) and Qi depression (11 times) ranked top three according to the frequency of constitution. Among facultative constitution, the top three were: Qi deficiency (18 cases, 33.33％),Yang deficiency (9 cases, 16.67％) and Qi depression (7 cases, 12.96％). There were 27 cases of deficiency constitution (50％), 20 cases of excess constitution (37. 04％). As compared to deficiency constitution, excess constitution and mild constitution had higher CD4 +T lymphocyte count, higher percentage of Th22, Th17 and Th1, but a lower percentage of Th2 and Treg(P ＜0. 05). Compared to excess constitution, mild constitution had a lower percentage of Th17. There was no statistical difference between the rest of the constitutions (P ＞0. 05). Compared with other deficiency constitutions, the CD4 + T lymphocyte count of the Qi deficiency constitution decreased(t =2. 724, P =0. 016),but there was no significant difference compared with CD4 +T lymphocyte subsets(P ＞ 0. 05). Conclusions There is a certain correlation between Chinese medical constitution type and CD4 +T lymphocyte count and its subsets. Qi deficiency runs through the process of HIV/AIDS, and the proportion of CD4 +T lymphocyte subsets imbalance in deficiency constitution is more obvious than those of excess constitution.关键词
人类免疫缺陷病毒/获得性免疫缺陷综合征/CD4+T淋巴细胞/淋巴细胞亚群/中医体质Key words
HIV/AIDS/CD4+T lymphocyte/lymphocyte subsets/Chinese medical constitution引用本文复制引用
俞冲,王忠成,朱勇根,徐海峰,邹美银,汪美华..获得性免疫缺陷综合征患者中医体质对CD4 + T淋巴细胞及其亚群的影响[J].中国中西医结合杂志,2018,37(11):1305-1309,5.基金项目
南通市科技局应用研究计划项目(No. BK2014082) （No. BK2014082）
